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CELLPURICS

GLOBAL CRO SERVICE

Biocytogen

Efficacy Evaluation Services

Based on extensive project experience and world-class research infrastructure, we support pharmacological evaluation studies for drug discovery and development.

영문 다이어그램
Antibody Therapeutics Tumor Vaccines CAR-T Cell Therapy Allergy Therapeutics Somatic Cell & Tissue Therapy Gene Therapy Recombinant Therapeutic Proteins PROTAC Oligonucleotide Drugs
  • In vivo
    Efficacy Evaluation

    Tumor Models

    Immune Reconstitution Models

    Autoimmune Disease Models

    Metabolic Disease Models

  • In vitro
    Pharmacology

    Binding Assay

    Fc Function Analysis
    (ADCC/ ADCP/ CDC)

    Fab Function Analysis

    Cell Enrichment & Culture

  • Ex vivo
    Pharmacology

    PD Analysis
    (Receptor Occupancy,
    Immune Profiling)

    TILs Analysis, Cytokine Analysis

    PK Analysis (Antibody Concentration, incl. ADA)

  • Pathology / Toxicity

    H&E / IHC & ICC / IF

    TMA Drug Screening

    Hematology Analysis

  • Translational Research
    (Canine)

    In vivo Efficacy Evaluation

    PK / PD

    Non-GLP Toxicity Evaluation

Case Studies

Asthma Model: OVA-induced Model on B-hIL4/hIL4RA mice

Efficacy Data Graph

Leukocyte infiltration and eosinophil content were significantly increased by OVA challenge in G2 model group, compared with G1 control group.
The number of CD45+ cells and eosinophils were significantly reduced after dupilumab (in-house) treatment.

Analysis of H&E staining in the lungs of asthmatic mouse models

H&E Staining Images

Results showed that no inflammatory cell infiltration in the pulmonary airway of G1 control group. Vascular and peribronchial inflammation (b) and mucus (a) secretion levels were increased in the G2 group, suggesting successful modeling. Inflammatory infiltration and mucus secretion were decreased in G3 group treated with dupilumab (in-house). These findings demonstrated that OVA successfully established an asthma model in B-hIL4/hIL4RA mice for efficacy evaluation.